Flavonoids are a large group of polyphenolic compounds present in almost all fruits and vegetables. Citrus accumulate particularly high amounts of flavonoids in albedo parts during immature stages and are an excellent source for the industrial isolation of these compounds. These active ingredients, specifically the citrus flavonoids, due to their antioxidant, venotonic, anti-inflammatory and antithrombotic properties have been used to address discomforts derived from a bad vascular system function.
Present in some plants and citrus fruits, the flavonoid diosmin can be obtained from the flavanone hesperidin, naturally present in the albedo part of immature sweet oranges. Ingrizo offers a diosmin-based phlebotonic, derived from sweet orange extracts, consisting of 90% diosmin and 10% other flavonoids expressed as hesperidin.
Various factors such as increased air travel, lack of exercise, pregnancy, improper diets, growing obesity, hereditary factors and aging are causing vascular problems. Poor circulation makes the blood to pool in the legs, enlarging the veins and causing varicose and spider veins. Venous reflux in legs can be caused by a malfunction of vein valves.
Diosmin formulation has been shown to have an effect on the processes involved in the microcirculation and it also modulates venous tone, prostaglandin synthesis, free radicals, complement activity and lymphatic drainage.
Following beneficial effects of diosmin formulation have been demonstrated:
Venotonic activity reduces the blood slow flow acting as a ‘chemical stocking’ against varicose and spider veins
Healing effect on venous ulcers and trophic skin disorders
Effective in reducing acute and chronic symptoms of hemorrhoids
Relief effect in swollen legs and edemas